2. Neurological Disease

Neurological Disease

Neurological Disease

Related Products

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-119492
    Phenchlobenpyrrone 215036-81-0 98%
    Phenchlobenpyrrone is a highly selective neuronal calcium antagonist that crosses the blood-brain barrier. Phenchlobenpyrrone mildly inhibits AChE activity. Phenchlobenpyrrone inhibits Aβ aggregation and promotes the clearance of Aβ oligomers. Phenchlobenpyrrone reduces abnormal phosphorylation of Tau protein. Phenchlobenpyrrone may be used in research on Alzheimer's disease.
    Phenchlobenpyrrone
  • HY-119495
    JTP 2942 148152-77-6 98%
    JTP 2942 is a thyrotropin-releasing hormone analogue. JTP 2942 can promote the release of Acetylcholine in the hippocampus and frontal cortex of rats. JTP 2942 possesses neuroprotective and cognitive-improving activities. JTP 2942 dose-dependently improves motor and neurological deficits in rat models of chronic focal cerebral ischemia. JTP 2942 can be used for the research of cerebral ischemia, motor neuron diseases, and other related conditions.
    JTP 2942
  • HY-119513
    Nizofenone 54533-85-6 98%
    Nizofenone is a neuroprotective agent which protects neurons from death following cerebral ischemia or anoxia. Nizofenone can be used in the research of acute neurological conditions, such as stroke.
    Nizofenone
  • HY-119519
    OB-2 300689-25-2 98%
    OB-2 is a STOML3 oligomerization blocker. OB-2 reverses pathological mechanical hypersensitivity. OB-2 can be used for research of painful diabetic neuropathy in mice.
    OB-2
  • HY-119552
    Acetylaszonalenin 42230-55-7 98%
    Acetylaszonalenin, a prenylated indole derivative, is a fungal metabolite.Acetylaszonalenin is a potent neurokinin-1 (NK1) receptor antagonist. Acetylaszonalenin shows inhibition of [3H]-SP binding to human astrocytoma cells with a Ki of 170 μM.
    Acetylaszonalenin
  • HY-119579
    Adamexine 54785-02-3 98%
    Adamexina is a derivative of bromhexine (HY-B0372), an expectorant. Adamexina, in addition to retaining the mucolytic effects of reducing sputum viscosity and promoting sputum excretion, also exhibits sympathomimetic and antiviral properties due to the introduction of an adamantyl group.
    Adamexine
  • HY-119581
    MBED 123363-40-6 98%
    MBED (9-Methyl-7-bromoeudistomin D) is a RyR agonist. MBED is a high-affinity caffeine-like probe, helps identify the caffeine-binding site in RyRs.
    MBED
  • HY-119592
    Cyclophostin 98%
    Cyclophostin is an acetylcholinesterase (AChE) inhibitor with IC50 values of 45, 0.76 and 1.3 nM for humans and two different insects, respectively.
    Cyclophostin
  • HY-119595
    Haloperidide 2924-46-1 98%
    Haloperidide (R3201) is a neuroleptic compound. Haloperidide is a potent and selective anti-emetic agent. Haloperidide antagonizes Apomorphine (HY-12723)-induced emesis in dogs.
    Haloperidide
  • HY-119605
    DAA-1097 220551-79-1 98%
    DAA-1097 is an orally active and selective agonist for the peripheral benzodiazepine receptor (PBR). DAA-1097 has anxiolytic effects.
    DAA-1097
  • HY-119615
    Mezilamine 50335-55-2 98%
    Mezilamine is a potent antidopaminergic agent. Mezilamine induces a concentration dependent increase in the electrically stimulated overflow of 3H-noradrenaline from rat cortical slices, without affecting the basal overflow. Mezilamine acts as a presynaptic α-adrenoceptor antagonist and a postsynaptic α-adrenoceptor agonist.
    Mezilamine
  • HY-119638
    Oxiperomide 5322-53-2 98%
    Oxiperomide is an orally active dopamine-blocking agent.
    Oxiperomide
  • HY-119705
    Prednival 15180-00-4 98%
    Prednival is a glucocorticoid. Prednival is used in studies of sustained-release ocular drug delivery.
    Prednival
  • HY-119716
    Cyheptamide 7199-29-3 98%
    Cyheptamide is an orally active anticonvulsant and antiepileptic agent. Cyheptamide exhibits moderate acute toxicity in animal models, with lethal doses varying by species specificity. Cyheptamide can be used in studies related to convulsions and epilepsy.
    Cyheptamide
  • HY-119733
    BU09059 1541206-05-6 98%
    BU09059 is a potent and selective Kappa-opioid receptor antagonist with a pA2 of 8.62. BU09059 has nanomolar affinity for the κ-receptor, with 15-fold and 616-fold selectivity over μ- and δ-receptors, respectively. BU09059 significantly blocks U50488 (HY-15997B)-induced antinociception.
    BU09059
  • HY-119744
    BAY 38-7271 212188-60-8 98%
    BAY 38-7271 is selective and highly potent and cannabinoid CB1/CB2 receptor agonist, with Kis of 1.85 nM and 5.96 nM for recombinant human CB1 receptor and CB2 receptor, respectively. BAY 38-7271 has strong neuroprotective properties.
    BAY 38-7271
  • HY-119765
    VU0366248 1243310-20-4 98%
    VU0366248 is a mGlu5 negative allosteric modulator.
    VU0366248
  • HY-119768
    (±)-BAK2-66 1301178-83-5 98%
    (±)-BAK2-66 is a selectivity dopamine D3 receptor antagonist with theKi values of 1nM and 960 nM for D3R and D2R, respectively. (±)-BAK2-66 can be used for study in animal models of addiction.
    (±)-BAK2-66
  • HY-119781
    Kaitocephalin 198710-92-8 98%
    Kaitocephalin (PF1191) is an ionotropic glutamate receptor (NMDAR) antagonist with Ki values of 7.8, 590, and 14000 nM for NMDAR, AMPAR, and KAR, respectively. Kaitocephalin protects neurons by inhibiting excitotoxicity, exhibiting neuroprotective effects. Kaitocephalin can be used in research on neurological diseases such as Alzheimer's disease.
    Kaitocephalin
  • HY-119795
    Zometapine 51022-73-2 98%
    Zometapine (CI-781) is a pyrazolodiazepine derivative. Zometapine can be used in antidepressant research.
    Zometapine
Cat. No. Product Name / Synonyms Application Reactivity